Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis
نویسندگان
چکیده
منابع مشابه
Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis
Of the four syntaxins specialized for exocytosis, syntaxin (Syn)-2 is the least understood. In this study, we used Syn-2/epimorphin knockout mice to examine the role of Syn-2 in insulin secretory granule (SG) exocytosis. Unexpectedly, Syn-2 knockout mice exhibited paradoxical superior glucose homeostasis resulting from an enhanced insulin secretion. This was confirmed in vitro by pancreatic isl...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2017
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db16-0636